A while ago I worked on the pilot for a show called 'Thriller Science' for Discovery Channel. The basic idea was to take a premise from a thriller novel and investigate the scientific merits of it. Throughout the doco we would cut to dramatisations of events described in the book.
Because of budget and time constraints we opted for a 'blue room' approach, using CG to flesh out the backgrounds and environments. I used mainly Lightwave for 3D and AfterEffects for compositing.
The show ultimately didn't get picked up for a series, as is usually the case with most of the pilots I have worked on.
ThrillerScience from Pete mullins on Vimeo.
ThrillerScience VFX breakdown from Pete mullins on Vimeo.